HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it stores a location in an external reference sequence along with a list of differences to the reference at that location as a sequence of "features". When decoding CRAM records, the reference data is stored in a char array, and parts matching the alignment record sequence are copied over as necessary. Due to insufficient validation of the feature data series, it was possible to make the `cram_decode_seq()` function copy data from either before the start, or after the end of the stored reference either into the buffer used to store the output sequence for the cram record, or into the buffer used to build the SAM `MD` tag. This allowed arbitrary data to be leaked to the calling function. This bug may allow information about program state to be leaked. It may also cause a program crash through an attempt to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

The remote Fedora 44 host has a package installed that is affected by multiple vulnerabilities as referenced in the FEDORA-2026-28858c383e advisory.

    Update pysam

    Resolves CVE issues

Tenable has extracted the preceding description block directly from the Fedora security advisory.

Note that Nessus has not tested for these issues but has instead relied only on the application's self-reported version number.

The remote Fedora 45 host has packages installed that are affected by multiple vulnerabilities as referenced in the FEDORA-2026-c383d4a134 advisory.

    Update to 1.23.1

Tenable has extracted the preceding description block directly from the Fedora security advisory.

Note that Nessus has not tested for these issues but has instead relied only on the application's self-reported version number.

The Linux/Unix host has one or more packages installed that are impacted by a vulnerability without a vendor supplied patch available.

  - HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which     stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based     compression so that instead of storing the full sequence for each alignment record it stores a location in     an external reference sequence along with a list of differences to the reference at that location as a     sequence of features. When decoding CRAM records, the reference data is stored in a char array, and     parts matching the alignment record sequence are copied over as necessary. Due to insufficient validation     of the feature data series, it was possible to make the `cram_decode_seq()` function copy data from either     before the start, or after the end of the stored reference either into the buffer used to store the output     sequence for the cram record, or into the buffer used to build the SAM `MD` tag. This allowed arbitrary     data to be leaked to the calling function. This bug may allow information about program state to be     leaked. It may also cause a program crash through an attempt to access invalid memory. Versions 1.23.1,     1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue. (CVE-2026-31966)

Note that Nessus relies on the presence of the package as reported by the vendor.

ID	Name	Product	Family	Severity
315365	Fedora 44 : python-pysam (2026-28858c383e)	Nessus	Fedora Local Security Checks	high
303035	Fedora 45 : bcftools / htslib / samtools (2026-c383d4a134)	Nessus	Fedora Local Security Checks	high
302965	Linux Distros Unpatched Vulnerability : CVE-2026-31966	Nessus	Misc.	medium

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CVE-2026-31966

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high

medium