ESRI ArcMap 9 and ArcGIS 10.0.2.3200 and earlier does not properly prompt users before executing embedded VBA macros, which allows user-assisted remote attackers to execute arbitrary VBA code via a crafted map (.mxd) file.
https://euvd.enisa.europa.eu/vulnerability/EUVD-2012-1671
http://www.securitytracker.com/id?1027170
http://www.exploit-db.com/exploits/19138
http://www.cs.umb.edu/~joecohen/exploits/CVE-2012-1661/
http://packetstormsecurity.org/files/113644/ESRI-ArcMap-Arbitrary-Code-Execution.html